Abstract:
Kinetic modeling of in vivo pyruvate-to-lactate conversion is essential for studying Warburg effect-modified cancer metabolism. Non-invasive metabolic flux detection may improve prognosis and treatment monitoring. Read also Image Processing Projects
Hyperpolarized [1–13-C] pyruvate was intravenously injected into 10 brain tumor patients to measure its rate of conversion to lactate (k_PL_) and bicarbonate (k_PB_) using echo-planar imaging. We investigated new methods for whole-brain k_PL_ and k_PB_maps. Read also Python Projects
The data-driven approach addressed two main issues: choosing the best model for our data and choosing a goodness-of-fit metric. An input-less model fit data best, according to statistical analysis. Selecting voxels based on post-fitting error criteria improved precision and spatial coverage over signal-to-noise cutoffs.
Note: Please discuss with our team before submitting this abstract to the college. This Abstract or Synopsis varies based on student project requirements.
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